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Zolpidem drug information
What is Zolpidem?
Zolpidem is a type of hypnotic GABA receptor agonist. It has similar qualities to benzodiazepine drugs and is prescribed for treating insomnia on a short-term basis. Zolpidem is better known by its brand name of Ambien but it is also available in many generic forms worldwide.
Zolpidem Indications
Zolpidem is indicated for the short-term treatment of insomnia. To avoid tolerance or dependency, Zolpidem should only be used for the shortest necessary time (about two weeks). It should never be used for longer than six weeks at a time. Because the effects of Zolpidem are not long lasting, it is typically only prescribed when the patient has problems falling asleep but does not have problems remaining asleep. Zolpidem may also be used for other purposes.
Zolpidem Mechanism of Action
Zolpidem works by acting on gamma-aminobutyric acid (GABA) receptors. GABA is the most widely-occurring neurotransmitter in the body with receptors throughout. Its main function is to inhibit neuron activity, thus producing a calming effect. GABA also is responsible for regulating muscular tone so Zolpidem also has muscle-relaxing qualities. These qualities do not however come out at normal dosage amounts of Zolpidem. Because Zolpidem has a short half-life (the time it takes half of the drug to be eliminated from the body), its sedating qualities are short lasting. This makes the drug only effective in helping insomniacs go to sleep, not stay asleep.
What You Should Know Before taking Zolpidem
If you take Zolpidem for a prolonged treatment cycle (can be as little as a couple weeks), your body may adjust itself to the effects of the medicine. This adjustment can cause you to develop a tolerance to Zolpidem in which the drug is not longer effective in you at normal dosages. Tell your doctor if Zolpidem stops helping you go to sleep. The adjustment may also cause a drug dependency to form in which your body needs Zolpidem in order to operate normally. Drug dependencies are marked by withdrawal symptoms when use of the drug is stopped. To safely stop taking Zolpidem after a dependency has developed, you may need to have your dosage reduced slowly over time.
Rebound Insomnia from Zolpidem
When you stop taking Zolpidem, it is common for you to experience troubles falling asleep again. This is called rebound insomnia and it usually will improve within 1-2 days. If your insomnia persists for several days after you stop taking Zolpidem, contact your doctor.
Zolpidem Withdrawal Symptoms
Suddenly stopping treatment with Zolpidem may cause withdrawal symptoms. How severe the symptoms are is related to how long you took the drug and in how large of dosages. Some Zolpidem withdrawal effects may include: insomnia, anxiety, mood swings, seizures, perspiration, body aches, and cramping, amongst others.
Side Effects from Zolpidem
It is common for Zolpidem to cause the following side effects: dizzy spells, sleepiness during normal waking hours, and symptoms similar to an alcohol hangover. These effects will generally diminish as your body becomes adjusted to the medicine. Tell your doctor if they persist or become worse. Though not likely, you should inform your doctor at once if you have these side effects which could be serious: unusual moods, severe forgetfulness, or hallucinating. In some rare cases, patients have reported sleep walking and performing other activities while asleep. This can be dangerous, particularly because some patients have driven or had sexual relations while asleep. If you find out that this has occurred, immediately tell your doctor. Talk to your doctor about precautions you can take against sleep walking and other sleep activities.
Who Should Not take Zolpidem?
Zolpidem may not be safe to use if you have certain health risk factors. You should not use Zolpidem until you have told your doctor your full medical history, especially if you have these conditions: respiration problems, hepatic impairment, impaired kidneys, psychiatric problems, you or a family member has abused drugs, myasthenia gravis, gastrointestinal problems, or allergies. Do not take Zolpidem while pregnant unless your doctor determines it is absolutely necessary. It could result in serious harm to your unborn child including neonatal dependency. Small amounts of Zolpidem is passed into breast milk. Do not breastfeed while using Zolpidem without first consulting your health care provider.
Interactions with Zolpidem
Do not start taking Zolpidem without first informing your doctor of all drugs/medications that you use, may use or have recently used. A serious or even fatal interaction could occur. These are just some of the possible interactions with Zolpidem: sodium oxybate, muscle relaxers, pain killers, narcotics, psychiatric medicines (including anti-anxiety and antidepressant drugs), antibiotics, medicine for fungal infections, or drugs which cause drowsiness. Avoid consuming alcohol while taking Zolpidem and read the labels on all over-the-counter medicines as they could cause drowsiness (particularly cough/flu treatments).
Overdose of Zolpidem
Never take more Zolpidem than you were prescribed as a serious or fatal overdose could take place. Some of the symptoms of an overdose on Zolpidem may include: respiratory depression and sleeping so deeply you cannot be awoken. If you suspect an overdose has occurred, get emergency medical treatment right away.