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Sildenafil Citrate drug information
Sildenafil Citrate Description and Indications
Sildenafil Citrate is generic drug called a PDE5 inhibitor. It is most commonly known by its brand name of Viagra though Sildenafil Citrate is also available in its generic form and under various brand names. Sildenafil Citrate is primarily used for treating erectile dysfunction, a condition in which a male has trouble getting or maintaining an erection during sexual activity. Sildenafil Citrate also treats the rare condition pulmonary arterial hypertension and may help to prevent altitude sickness. Sildenafil Citrate may also be used for other purposes which are not discussed here.
How Does Sildenafil Citrate Work?
During sexual stimulation, a series of complex chemical reactions occur which leads to an erection. Simplified, these reactions include nitric oxide binding to certain receptors and causing GMP levels to increase. GMP causes smooth muscle tissue to relax thus increasing blood flow to the penis and resulting in erection. Normally, an enzyme called phosphodiesterase type 5 (PDE5) breaks down GMP and causes the penis to become flaccid again. The way that Sildenafil Citrate works is by inhibiting PDE5. Without PDE5 to degrade GMP, erections became harder and longer lasting. Sildenafil Citrate will not cause erections without sexual stimulation. Because the half life of Sildenafil Citrate is about 3-4 hours, it is suitable for the short-term treatment of erectile dysfunction.
Sildenafil Citrate Dosage and Administration
The majority of patients will be advised to take Sildenafil Citrate in dosages of 50 mg about 60 minutes before engaging in sexual activities. Under the brand name Viagra, patients may take Sildenafil Citrate up to about 4-0.5 hours before sexual activities. This dosage may be increased or decreased as needed to a low of 25 mg or high of 100 mg. Patients with certain health factors, including patients over 65 years old, should have treatment with Sildenafil Citrate initiated in dosages of 25 mg. Unless otherwise directed, you may take Sildenafil Citrate without regards to meals. Never take more than one tablet of Sildenafil Citrate in a period of 24 hours. Tablets of Sildenafil Citrate should always be swallowed whole. Do not chew, break or snort them.
What Does Sildenafil Citrate Look Like?
Under the brand name Viagra, Sildenafil Citrate comes as blue, diamond-shaped tablets. These tablets are film coated, have Pfizer incised on one side, and have VGR plus their corresponding dosage amount on the other side (ex. VGR25). However, Sildenafil Citrate is available in many generic forms so your medicine may look different than Viagra.
Common Sildenafil Citrate Side Effects
Sildenafil Citrate commonly causes some adverse effects which are not generally serious. The following side effects occurred in at least 2% of patients taking Sildenafil Citrate: headaches, a warm/tingly feeling, gastrointestinal disturbances, stuffy nose, urinary tract infections, changes to eyesight (perceiving color differently, fuzziness), loose stools, dizziness, and rashes. If any of these side effects from Sildenafil Citrate are severe, continual or get worse, you should notify your doctor.
Serious Side Effects from Sildenafil Citrate
Sildenafil Citrate is generally well tolerated in most patients and is not likely to cause serious side effects. One of the serious problems thought to be caused by Sildenafil Citrate is NAION, a blindness which suddenly occurs in either or both eyes. This is more likely if you have certain risk factors including ocular or heart problems. You should get medical help at once if NAION occurs. Sildenafil Citrate may cause males to have priapism which may be serious are require surgical operation. Get medical help right away if your erection lasts over 4 hours or hurts. During sexual activity, your heart may be strained. This strain can be worsened by Sildenafil Citrate, thus causing cardiovascular problems. Immediately stop physical activity and get medical attention if you have these symptoms while using Sildenafil Citrate: becoming very dizzy, you faint, angina, jaw pain, or pain/weakness in left arm/side. In rare cases, Sildenafil Citrate may lead to impaired hearing. Get medical attention at once if this occurs.
Sildenafil Citrate Contraindications
Sildenafil Citrate is not the right medicine for everyone. Patients who have certain health risk factors may not be able to take Sildenafil Citrate at all or may need to initiate treatment on lower dosages. Do not take Sildenafil Citrate if your doctor has advised you from engaging in sexual activities or other physical activities because of risk of cardiovascular problems. Sildenafil Citrate should also not be taken if you have: recently had a stroke/heart attack, certain retina problems, low blood pressure, impaired renal functioning, or liver problems. It may also not be cause for you to use Sildenafil Citrate if you have: sickle cell disease, hypertension, history of prolonged/painful erections, ocular problems, cardiovascular complications, impaired kidneys, lung containing fluids, penile problems, or allergies.
Interactions with Sildenafil Citrate
Sildenafil Citrate must not be taken with Nitrate drugs because a serious interaction could occur. Some of these drugs may include glyceryl trinitrate or "poppers." Other drugs and natural products can also interact with Sildenafil Citrate so do not take this medicine without first informing your doctor of all treatments that you use, especially of: anti-seizure medicine, medicine for fungal infections, antibiotic drugs, antiviral drugs, angina medicines, other treatments for erectile dysfunction, or St. John's wort.