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Sibutramine drug information
What is Sibutramine?
Sibutramine is a type of appetite suppressant drug which is used for promoting weight loss in obese or overweight patients. It is a type of serotonin-norepinephrine reuptake inhibitor (SNRI). Sibutramine was initially developed as an antidepressant drug but failed to exhibit these properties. Instead, it was found effective in treating obesity by decreasing cravings for food and causing a feeling of fullness. Sibutramine was first approved by the FDA in 1997. However, it was withdrawn from the market in many nations under pressure from various health organizations, including the FDA and Health Canada, because of possible of serious cardiovascular side effects.
Sibutramine Indications
Sibutramine is indicated for treating obesity and helping to maintain weight lost by obese patients. Sibutramine is typically only advised for use in patients who have a body mass index of 30+ or 27+ if they are at risk for various health conditions related to their obesity. Sibutramine should only be used along with other lifestyle methods of weight loss/weight maintenance including a low-calorie diet and exercising.
Sibutramine Dosage Information
Always take Sibutramine exactly as it was prescribed and never in higher dosage amounts. The standard starting dosage of Sibutramine is 10mg which is taken once per day without regards to meals. For the best effects, Sibutramine should be taken regularly and at the same times every day. Treatment with Sibutramine should be reevaluated by a doctor on a regular basis. Patients who are intolerant to the standard Sibutramine dosage may have their dosage reduced to 5mg. Patients who lose less than 4 lbs during the first month of treatment may have their dosage increased to a maximum of 15mg taken once per day. Alternatively, the doctor may decide to stop treatment with Sibutramine. Studies show that patients who do not lose significant weight with Sibutramine in the first month are not likely to lose weight with continual treatment.
What Results Can You Expect from Sibutramine?
When used along with a low-calorie diet and exercise program, Sibutramine has proven very effective in helping weight loss in obese patients. Controlled studies with Sibutramine showed that the drug can effectively help obese patients lose about 7% of their body weight. However, Sibutramine was not effective for all patients. The studies showed that 2/3 of the patients which lost 4 lbs during the first month of treatment went on to lose a minimum of 5% of their body weight within 6-12 months. Of the patients who did not lose 4 lbs during this first month of treatment, 4/5 of them did not lose 5% of their body weight within 6-12 months. The effectiveness of Sibutramine may be in part due to the patient's response to the medicine as well as how well the patient maintains the dietary and exercise portions of the weight-loss program with Sibutramine.
Sibutramine Side Effects
While taking Sibutramine, these side effects are common but usually not serious: changes to appetite, feeling nauseous, decreased salivation, unusual tastes in mouth, dyspepsia, infrequent bowel movements, insomnia, dizzy spells, fatigue, pain during menstruation, headaches, becoming hot all over, or pains in joints/muscles. These effects will usually diminish as your body adjusts to Sibutramine. Tell your doctor if they continue or become worse. Sibutramine may lead to serious health conditions. You should notify your doctor at once if you have any of these adverse effects during treatment: rapid/thumping/erratic heart beats, numb/tingly feeling in extremities, unusual moods/behaviors, change of urine color or amount, become bruised easily, dark excrement, bloody vomit (may be dark and gritty), abnormal perspiration, or swollen limbs. If you have any of these dire adverse effects, get medical help with due haste: convulsions, chest pains, weakness/numbing on one side, sudden change to eyesight, breathlessness, unusual moods or changes to mental health (including delusions or becoming very restless), unsteadiness, unusual fever, or unrelenting diarrhea/nausea. Get medical help for an allergic reaction at once.
Warnings about Sibutramine
Sibutramine was recalled from the market in many countries (including the United States, United kingdom, India, Mexico, and EU) because of possible risk of serious health complications. A controlled study of Sibutramine called SCOUT and consisting of approximately 10,700 patients showed that Sibutramine may increase the chances of cardiovascular problems. If you are currently using Sibutramine, you should consult your doctor about whether you should stop using this drug or find a safer form of weight-loss.
Who Should Not Take Sibutramine?
Do not take Sibutramine if you are older than 65 years or have any of these conditions: bulimia, anorexia nervosa, untreated hypertension, cardiovascular problems, circulatory problems, or history of stroke. It may be unsafe for you to use Sibutramine if you have: allergies, glaucoma, hypothyroidism, impaired liver, impaired kidneys, gallstone problems, seizures, blood-related problems, psychiatric disorders, or drug dependency/abuse.
Overdose of Sibutramine
Do not take more Sibutramine than advised as a serious life-threatening overdose may occur. If you think that an overdose of Sibutramine has taken place, you should immediately seek emergency medical attention or contact your area's poison control helpline. The exact symptoms of Sibutramine are currently not known but it may include become flushed or sweating.