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Orlistat drug information
Orlistat: Description and Indications
Orlistat is the active generic ingredient in the prescription weight-loss drug Xenical. It is also available in its generic form from some manufacturers. Orlistat is classified as a lipase inhibitor and works by preventing the intestines from breaking down and absorbing fats. This property makes Orlistat effective in promoting weight loss. Orlistat is indicated for supplementing weight loss in obese patients or overweight patients who are at risk for serious health problems such as hypertension or diabetes. It should only be used in addition to a low-calorie, healthy diet for promoting weight loss.
How Does Orlistat Work?
When fatty foods are consumed, they are typically passed into the intestines where they are broken down so they may be absorbed by the body. The compounds responsible for breaking down fats are called lipases. The way that Orlistat works is by stopping the actions of lipases, thus preventing fats from breaking down. Instead of being absorbed by the body, the fats are excreted from the body as stools. This, in addition to a healthy diet and lifestyle choices, has proven effective in promoting weight loss. However, there is also evidence that Orlistat helps weight loss through aversion therapy. As the drug is known to cause very unpleasant adverse effects when fatty meals are consumed, patients are discouraged to eat unhealthy, high-fat foods which can contribute to weight-loss and overall health on a long-term basis.
Orlistat Dosing and Administering
Most commonly, Orlistat comes in capsule forms. The dosage amount should be determined by a doctor based on condition and other factors such as medical history. Typically, Orlistat dosage is 120 mg which is taken with meals (usually three times per day) or a maximum of 1 hour after eating a meal. To avoid very unpleasant adverse effects, meals should be low-fat (no more than 30% of caloric value from fats). As Orlistat is only effective in promoting weight loss by preventing absorption of fats, it does not need to be taken with meals which contain no fat.
Notes about taking Orlistat
Orlistat can interfere with the way that the body absorbs certain vitamins, minerals and medications, particularly those which are fat soluble. To prevent a vitamin/mineral deficiency, you may be instructed to take a supplement during treatment. This supplement should be taken a minimum of two hours before or after taking Orlistat. You should follow all instructions about taking Orlistat with other medications. Some medications, such as Levothyroxine, should be taken a minimum of four hours before or after taking Orlistat.
Common Side Effects from Orlistat
Orlistat is known to produce some very unpleasant gastrointestinal side effects. Some of these side effects may include: fatty stools, inability to control bowels, feeling sudden need to pass bowels, oil-like discharge from anus, gas, and flatulence with oily discharges. In about half of the cases, these effects lasted less than one week and, in most cases, less than one month. However, some patients may experience unpleasant side effects for the full duration of treatment. To avoid these unpleasant side effects while taking Orlistat, you should minimize the amounts of fats in your diet. Other common Orlistat side effects which are usually not serious may include: headaches, stomachache, or diarrhea.
Potential Serious Orlistat Side Effects
If you have any of these side effects while using Orlistat, you should tell your doctor right away: troubles breathing, unusual fatigue, severe/chronic nausea or abdominal pains, jaundice, darkened urine, or pale stools. You should get medical help at once if you have any of these potentially serious side effects from Orlistat: chest pains, sudden changes to vision/hearing/cognitive abilities, numbness/weakness in one side, or signs of an allergic reaction (may include rashes, hives, troubles with how you breathe, or swelling to facial/oral areas).
Who Should Not Use Orlistat?
Orlistat is not the right weight-loss drug for everyone. In some patients, it could be dangerous to use. Do not take Orlistat without first consulting with your doctor or pharmacist and making them aware of your health status. The following are just some of the conditions which may make it unsafe for you to use Orlistat: allergies, liver impairment, eating disorders, vitamin/mineral deficiencies, diabetes, gallbladder problems, pancreatic disease, or gastrointestinal problems.
Orlistat during Pregnancy and Breastfeeding
Currently, there has been no human testing to determine whether Orlistat is safe during pregnancy. Animal testing shows that Orlistat will not likely harm a fetus or cause infertility. However, it is advised against using Orlistat while pregnant as it can impede with healthy fat, vitamin, and mineral absorption which is needed for a fetus to develop. Do not take Orlistat while pregnant without first consulting your doctor. Discuss other methods of treating obesity while pregnant. It is unknown if Orlistat is passed into breast milk and could harm a nursing child. Do not take Orlistat while breastfeeding without first discussing the risks with your doctor.